منابع مشابه
ATP mediates tubuloglomerular feedback.
THE MACULA DENSA CELLS COMPRISE the sensing component of the tubuloglomerular feedback (TGF) mechanism and respond to changes in tubular fluid composition by transmitting signals to the afferent arterioles thus regulating the preglomerular vascular resistance and filtered load to the tubules (14, 15). This intriguing mechanism has remained under intensive investigation, and the accrued evidence...
متن کاملAdenosine mediates tubuloglomerular feedback.
VARIATIONS OF NaCl concentration in the macula densa region of the tubule between 20 and 60 mM/l cause inverse changes in glomerular filtration rate (GFR) that, for the most part, are the result of a progressive increase in afferent arteriolar resistance and a subsequent fall in glomerular capillary pressure (5). The reductions in capillary pressure and GFR are rapidly inducible and rapidly rev...
متن کاملCalcium wave of tubuloglomerular feedback.
ATP release from macula densa (MD) cells into the interstitium of the juxtaglomerular (JG) apparatus (JGA) is an integral component of the tubuloglomerular feedback (TGF) mechanism that controls the glomerular filtration rate. Because the cells of the JGA express a number of calcium-coupled purinergic receptors, these studies tested the hypothesis that TGF activation triggers a calcium wave tha...
متن کاملTubuloglomerular feedback in Dahl rats.
We have previously demonstrated a loss of autoregulation in Dahl salt-sensitive (Dahl-S) rats rendered hypertensive on a high-salt diet. To determine whether this was due to a decreased activity of either the myogenic or the tubuloglomerular feedback (TGF) response, we tested the TGF response in both Dahl-S and salt-resistant Dahl rats on high- and low-salt diets. TGF was investigated in the cl...
متن کاملNystatin and valinomycin induce tubuloglomerular feedback.
The macula densa expresses a luminal Na(+)-K(+)-2Cl(-) cotransporter and a basolateral Cl(-) conductance. Although it is known that cotransport of Na(+), K(+), and Cl(-) is the first step in tubuloglomerular feedback (TGF), subsequent steps are unclear. We hypothesized that Na(+)-K(+)-2Cl(-) entry via the luminal Na(+)-K(+)-2Cl(-) cotransporter elevates intracellular Cl(-), increases electrogen...
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ژورنال
عنوان ژورنال: Japanese Heart Journal
سال: 1996
ISSN: 0021-4868,1348-673X
DOI: 10.1536/ihj.37.153